Epigenome-wide change and variation in DNA methylation in childhood: Trajectories from birth to late adolescence
08/04/2021 - Janine Felix, Vincent Jaddoe - Erasmus MC
Cohort(s): ALSPAC, Generation R
DNA methylation is an important biological process in childhood health and development, but a comprehensive characterisation of genome-wide DNAm trajectories across this age period is currently lacking. In this manuscript, we used data from epigenome-wide association studies in 5,019 blood samples collected at multiple time-points from birth to late adolescence from 2,348 participants of two large independent cohorts to characterize DNAm trajectories over time. We found that DNAm levels change over time in more than half of the DNAm sites and we describe these changes. Our findings support a developmental role for DNA methylation that extends beyond birth into late adolescence and has implications for understanding life-long health and disease. DNAm trajectories can be visualized at http://epidelta.mrcieu.ac.uk.