Fetal exposure to phthalates and bisphenols and DNA methylation at birth: the Generation R Study
10/10/2022 - Sol C.M. et al. Clinical Epigenetics. LongITools authors: Susana Santos, Vincent Jaddoe and Janine Felix. - Erasmus MC
Cohort(s): Generation R
Phthalates and bisphenols are non-persistent endocrine disrupting chemicals that are ubiquitously present in our environment and may have long-lasting health effects following fetal exposure. We examined if changes in DNA methylation are a biological mechanism that underlies these health effects. Although we did not identify genome-wide significant results, we identified some suggestive associations of exposure to a maternal mixture of phthalates and bisphenols in the first and second trimester with DNA methylation in cord blood that need further exploration in larger study samples.