Associations of circulating folate, vitamin B12 and homocysteine concentrations in early pregnancy and cord blood with epigenetic gestational age: the Generation R Study
29/04/2021 - Monasso G.S. et al. Clinical Epigenetics. LongITools authors: Vincent Jaddoe and Janine Felix - Erasmus MC
Cohort(s): Generation R
Concentrations of folate, vitamin B12 and homocysteine during pregnancy are associated with childhood health outcomes. In a population-based study of 1,346 mothers and newborns, we found some evidence to support associations of maternal plasma homocysteine concentrations with positive epigenetic gestational age acceleration, suggesting faster epigenetic than clinical gestational ageing. Cord serum vitamin B12 concentrations may be associated with negative gestational age acceleration, indicating slower epigenetic than clinical gestational ageing.