Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes
16/01/2024 - J.P. Bradfield et al. Genome Biology. LongITools authors: Zhanna Balkiyarova, Anni Heiskala, Janine Felix, Vincent Jaddoe, Marjo-Riitta Järvelin, Sylvain Sebert, Nicholas Timpson and Inga Prokopenko - University of Surrey, Erasmus MC, University of Oulu, Imperial College London, University of Bristol
The researchers report novel genetic associations with the tempo of pubertal growth and find that genetic determinants of growth are correlated with reproductive, glycemic, respiratory, and cardiac traits in adulthood. These results aid in identifying specific growth trajectories impacting lifelong health and show that there may not be a single “optimal” pubertal growth pattern.